Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prox1  prospero homeobox 1   (Synonyms: A230003G05Rik)
Results	Reference
1	J:173382 Basch ML, Ohyama T, Segil N, Groves AK, Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj{kappa}. J Neurosci. 2011 Jun 1;31(22):8046-58
1	J:330573 Bonet F, Anez SB, Inacio JM, Futschik ME, Belo JA, CCBE1 Is Essential for Epicardial Function during Myocardium Development. Int J Mol Sci. 2022 Oct 20;23(20)
1	J:186594 Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S, CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. Circ Res. 2011 Aug 19;109(5):486-91
1*	J:206581 Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, Francois M, Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 1;386(1):25-33
1	J:158529 Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V, Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010;10:13
1*	J:136688 Buttler K, Ezaki T, Wilting J, Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics. BMC Dev Biol. 2008;8:43
1*	J:108556 Buttler K, Kreysing A, von Kaisenberg CS, Schweigerer L, Gale N, Papoutsi M, Wilting J, Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos. Dev Dyn. 2006 Jun;235(6):1554-1562
1	J:139969 Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU, Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol. 2008 Sep 15;321(2):420-33
1	J:344154 Carlantoni C, Liekfeld LMH, Hemkemeyer SA, Schreier D, Saygi C, Kurelic R, Cardarelli S, Kalucka J, Schulte C, Beerens M, Mailer RK, Schaffer TE, Naro F, Pellegrini M, Nikolaev VO, Renne T, Frye M, The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling. Dev Cell. 2023 Dec 23;
1	J:212971 Cavalheiro GR, Matos-Rodrigues GE, Gomes AL, Rodrigues PM, Martins RA, c-myc regulates cell proliferation during lens development. PLoS One. 2014;9(2):e87182
1	J:233304 Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS, Mechanotransduction activates canonical Wnt/beta-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 Jun 15;30(12):1454-69
1	J:301556 Cha B, Ho YC, Geng X, Mahamud MR, Chen L, Kim Y, Choi D, Kim TH, Randolph GJ, Cao X, Chen H, Srinivasan RS, YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development. 2020 Dec 13;147(23):dev195453
1	J:237076 Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT, CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 Jun 01;126(6):2254-66
1	J:93150 Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW, Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004 Oct;4(6):611-9
1	J:344351 Deska-Gauthier D, Borowska-Fielding J, Jones C, Zhang H, MacKay CS, Michail R, Bennett LA, Bikoff JB, Zhang Y, Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity. Cell Rep. 2023 Dec 29;43(1):113635
1	J:143564 Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Tutt D, Cheah KS, Stacker SA, Muscat GE, Achen MG, Dejana E, Koopman P, Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008 Dec 4;456(7222):643-7
1	J:130930 Fritz-Six KL, Dunworth WP, Li M, Caron KM, Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest. 2008 Jan;118(1):40-50
1	J:208880 Gauvrit S, Philippe J, Lesage M, Tjwa M, Godin I, Germain S, The role of RNA interference in the developmental separation of blood and lymphatic vasculature. Vasc Cell. 2014;6(1):9
1	J:228882 Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MK, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS, Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016 Jan 1;409(1):218-33
1*	J:266923 Grifone R, Saquet A, Xu Z, Shi DL, Expression patterns of Rbm24 in lens, nasal epithelium, and inner ear during mouse embryonic development. Dev Dyn. 2018 Oct;247(10):1160-1169
1	J:252596 Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF Jr, Trivedi CM, Hdac3 regulates lymphovenous and lymphatic valve formation. J Clin Invest. 2017 Nov 1;127(11):4193-4206
1*	J:139639 Juszynski M, Ciszek B, Stachurska E, Jablonska A, Ratajska A, Development of lymphatic vessels in mouse embryonic and early postnatal hearts. Dev Dyn. 2008 Sep 24;237(10):2973-2986
1	J:218198 Kaltezioti V, Antoniou D, Stergiopoulos A, Rozani I, Rohrer H, Politis PK, Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons. J Neurosci. 2014 Nov 19;34(47):15816-31
1	J:173649 Kanady JD, Dellinger MT, Munger SJ, Witte MH, Simon AM, Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev Biol. 2011 Jun 15;354(2):253-66
1*	J:161985 Karunamuni G, Yang K, Doughman YQ, Wikenheiser J, Bader D, Barnett J, Austin A, Parsons-Wingerter P, Watanabe M, Expression of lymphatic markers during avian and mouse cardiogenesis. Anat Rec (Hoboken). 2010 Feb;293(2):259-70
1	J:225799 Kazenwadel J, Betterman KL, Chong CE, Stokes PH, Lee YK, Secker GA, Agalarov Y, Demir CS, Lawrence DM, Sutton DL, Tabruyn SP, Miura N, Salminen M, Petrova TV, Matthews JM, Hahn CN, Scott HS, Harvey NL, GATA2 is required for lymphatic vessel valve development and maintenance. J Clin Invest. 2015 Aug 3;125(8):2979-94
1*	J:122404 Kim KE, Sung HK, Koh GY, Lymphatic development in mouse small intestine. Dev Dyn. 2007 Jul;236(7):2020-5
1*	J:141989 Kirjavainen A, Sulg M, Heyd F, Alitalo K, Yla-Herttuala S, Moroy T, Petrova TV, Pirvola U, Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Dev Biol. 2008 Oct 1;322(1):33-45
1	J:214795 Klein KR, Karpinich NO, Espenschied ST, Willcockson HH, Dunworth WP, Hoopes SL, Kushner EJ, Bautch VL, Caron KM, Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014 Sep 8;30(5):528-40
1*	J:99326 Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H, Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
1*	J:151925 Li Y, Piatigorsky J, Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development. Dev Dyn. 2009 Sep;238(9):2388-400
1*	J:310860 Liu S, Wang Y, Lu Y, Li W, Liu W, Ma J, Sun F, Li M, Chen ZY, Su K, Li W, The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns. Neural Plast. 2018;2018:7513258
1	J:316476 Ma W, Gil HJ, Liu X, Diebold LP, Morgan MA, Oxendine-Burns MJ, Gao P, Chandel NS, Oliver G, Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance. Sci Adv. 2021 Apr;7(18)
1	J:244306 Mahadevan A, Welsh IC, Sivakumar A, Gludish DW, Shilvock AR, Noden DM, Huss D, Lansford R, Kurpios NA, The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine. Dev Cell. 2014 Dec 22;31(6):690-706
1	J:284120 Mahamud MR, Geng X, Ho YC, Cha B, Kim Y, Ma J, Chen L, Myers G, Camper S, Mustacich D, Witte M, Choi D, Hong YK, Chen H, Varshney G, Engel JD, Wang S, Kim TH, Lim KC, Srinivasan RS, GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019 Nov 5;146(21):dev184218
1	J:329978 Maruyama K, Miyagawa-Tomita S, Haneda Y, Kida M, Matsuzaki F, Imanaka-Yoshida K, Kurihara H, The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse. Elife. 2022 Oct 5;11:e81515
1*	J:278916 Maruyama K, Miyagawa-Tomita S, Mizukami K, Matsuzaki F, Kurihara H, Isl1-expressing non-venous cell lineage contributes to cardiac lymphatic vessel development. Dev Biol. 2019 Aug 15;452(2):134-143
1	J:330186 Nguyen H, Sokpor G, Parichha A, Pham L, Saikhedkar N, Xie Y, Ulmke PA, Rosenbusch J, Pirouz M, Behr R, Stoykova A, Brand-Saberi B, Nguyen HP, Staiger JF, Tole S, Tuoc T, BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain. Front Cell Dev Biol. 2022;10:1011109
1	J:149138 Norrmen C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Yla-Herttuala S, Alitalo K, Petrova TV, FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol. 2009 May 4;185(3):439-57
1	J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1	J:282057 Pawlak JB, Balint L, Lim L, Ma W, Davis RB, Benyo Z, Soares MJ, Oliver G, Kahn ML, Jakus Z, Caron KM, Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. J Clin Invest. 2019 Nov 1;129(11):4912-4921
1	J:158668 Qu X, Tompkins K, Batts LE, Puri M, Baldwin S, Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice. Development. 2010 Apr;137(8):1285-95
1	J:219810 Qu X, Zhou B, Scott Baldwin H, Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol. 2015 Mar 1;399(1):117-28
1	J:144217 Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR, Prox1 maintains muscle structure and growth in the developing heart. Development. 2009 Feb;136(3):495-505
1	J:146692 Saint-Geniez M, Kurihara T, D'Amore PA, Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):311-21
1	J:137035 Solberg N, Machon O, Krauss S, Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev Dyn. 2008 Jul;237(7):1799-811
1*	J:217439 Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G, The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014 Oct 1;28(19):2175-87
1	J:158959 Srinivasan RS, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, Porto MP, Lagutin O, Oliver G, The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 2010 Apr 1;24(7):696-707
1	J:177488 Srinivasan RS, Oliver G, Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011 Oct 15;25(20):2187-97
1	J:278572 Stone OA, Stainier DYR, Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. Dev Cell. 2019 Jul 22;50(2):247-255.e3
1	J:237527 Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S, Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 01;143(21):3994-4002
1	J:215000 Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO, Integrin-alpha5beta1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. Dev Biol. 2014 Aug 15;392(2):381-92
1	J:336858 Vallecillo-Garcia P, Orgeur M, Comai G, Poehle-Kronnawitter S, Fischer C, Gloger M, Dumas CE, Giesecke-Thiel C, Sauer S, Tajbakhsh S, Hopken UE, Stricker S, A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation. Immunity. 2023 Jun 13;56(6):1204-1219.e8
1	J:183127 Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B, Pancreas-specific deletion of prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology. 2012 Apr;142(4):999-1009.e6
1*	J:143210 Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ, Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes. Dev Dyn. 2008 Dec;237(12):3681-9
1	J:109778 Zhou CJ, Pinson KI, Pleasure SJ, Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants. J Neurosci. 2004 Sep 1;24(35):7632-9